Hacker Newsnew | past | comments | ask | show | jobs | submit | yccs27's commentslogin

Does "Pharma" actually dose medication based on the Eyring equation? I'm not convinced we actually know the value of ΔG. AFAIK, the optimal biological dose is determined via dose-ranging studies during Phase I/II of clinical trials. And drug metabolism rate is measured, not derived from theoretical models.


Road capacity does not increase with speed above 50 km/h on urban roads or 70 km/h on highways. Following distance scales with speed, so more speed can actually mean fewer cars per unit of time.

In theory, braking distance scales quadratically with speed. In practice, people leave less room on highways, because they rely on others driving predictably, but spacing still increases faster than linear.


I'm not so sure this is really a free market equilibrium. There are two effects which explain the prevalence of ads even if consumers are willing to pay more for ad-free products:

- Imperfect information, aka Market for Lemons: It can be hard to find out how prevalent ads will be when buying a product. Consumers often make a purchasing decision without knowledge about ads.

- Changing terms after lock-in, aka Enshittification: Manufacturers (like Hisense here) can add advertising to products after consumers have already bought them. Initially, consumers have negotiation power since they can freely choose a product, but later they are locked in and cannot easily react to the manufacturer changing the product to their detriment.


The last line of the introduction

> By doing so, we aim to provide a novel paradigm [...]

also made me think of item 19 on your list:

> 10 points for claiming that your work is on the cutting edge of a "paradigm shift".

I'm sad though that you didn't call it the "Baez crackpot index"...


This reads a lot like an advertisement. The linked page [[Cyclorotor]] is more neutral and has more information on the design and applications outside of marine vessels:

https://en.wikipedia.org/wiki/Cyclorotor


This is conceptually significant because the article links the mechanisms used in watercraft and aircraft.


It‘s preying on the city‘s desperation to get a cash payout, to get space and utilities worth much more. Facebook abuses its market power to pit city governments against each other, while the cities don‘t have many alternatives.


Does the mayor sell land or electricity now? That’s not how one gets space or utilities.


The saying probably assumes that each chronometer has a certain small probability of malfunctioning, resulting in a significant error (basically a fat-tailed error distribution). With three chronometers, you can use a robust estimator of the true value (consensus value or median). With two, there's no robust estimator and if you use the mean, you have twice the probability of being significantly wrong (though only by half as much).


Thanks for the link, nice to see the informal conventions spelled out like this!


True, although better pruning can massively lower the effective branching ratio compared to pure alpha-beta, making the algorithm benefit more from longer search time again (which is why pruning is so important).


Users with enough karma can "flag" posts and comments, which a) calls for moderator attention and b) decreases ranking. It's meant for off-topic/inflammatory/low-quality submissions.


Consider applying for YC's Summer 2026 batch! Applications are open till May 4

Guidelines | FAQ | Lists | API | Security | Legal | Apply to YC | Contact

Search: