I've been working for a Ketamine Clinic the past few months, and it's fascinating to learn about (bunch of good resources here: https://www.fargoketamineclinic.com ). While it can be incredibly addicting, it's also opening new research into solving depression. Because it works differently than traditional antidepressants by targeting the NMDA receptors and binding to them to increase glutamate, it could vastly help people with treatment resistant depression. The problem is that with high doses like this article suggests, it can be dangerous. So it's a complicated area.