None of the reported snps (rs9320913, rs11584700, rs4851266) have been mentioned in any other publication. So I don't yet see a basis for "the hits seem to be replicating pretty well".
I do not doubt that genetics plays a significant role in intelligence, but I expect that intelligence, and the proxy of educational attainment, is an overly broad phenotype. I also expect that epistatic effects may be important and would necessitate unrealistically massive sample size or a very different experimental design.
Yes, since people upped their game precisely because of that paper's findings...
> None of the reported snps (rs9320913, rs11584700, rs4851266) have been mentioned in any other publication. So I don't yet see a basis for "the hits seem to be replicating pretty well".
What do you mean? As I recall, Rietveld et al 2013 used internal replication to test its hits, which worked out well. Your link is itself a another replication of Rietveld et al 2013, is it not? (What exactly did you think the abstract meant when it talked about "A recent genome-wide-association study" or "The study"?) And then there's "Genetic Variation Associated with Differential Educational Attainment in Adults Has Anticipated Associations with School Performance in Children" , Ward et al 2014; and I believe "Educational attainment-related loci identified by GWAS are associated with select personality traits and mathematics and language abilities", Zhu et al 2015 is also relevant.
> Rietveld replicating Rietveld doesn't do it for me in an area so lacking of success stories.
I think this is unreasonable. This is not a lone author working with a set he hand-collected and has had unlimited freedom to monkey with. This is the lead author on a project involving scores of authors analyzing vast datasets pooled together by like a dozen distinct organizations.
I appreciate the replies. I learned a lot just reading some of these sources posted. I think I misused heritability regarding eye color and my numbers are probably dated.
The most current information I see is Rietveld published 10 days ago. http://pss.sagepub.com/content/early/2014/10/06/095679761454... and that paper claims to have found an explanation for ≈2% of educational attainment and cognitive function.
None of the reported snps (rs9320913, rs11584700, rs4851266) have been mentioned in any other publication. So I don't yet see a basis for "the hits seem to be replicating pretty well".
I do not doubt that genetics plays a significant role in intelligence, but I expect that intelligence, and the proxy of educational attainment, is an overly broad phenotype. I also expect that epistatic effects may be important and would necessitate unrealistically massive sample size or a very different experimental design.